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John R. Lee, M.D.
Natural Hormone Balance

Eating Meat and Eggs Does not Increase Breast Cancer Risk
During the 90s, much ado was made about a possible link between eating saturated fat and increased breast cancer risk. In most of the research, consumption of hydrogenated oils (trans fatty acids) was never accounted for or if it was, it was not published. As time passed, this link was discounted, primarily because of the weakness of the studies, so I was glad to see evidence showing that breast cancer is not associated with meat or egg consumption. Eggs are one of the healthiest foods you can eat, and hormone-free meat supplies valuable high quality protein. The researchers are associated with the famous Nurses’ Health Study in Boston, and examined data on diet and breast cancer. The 88,647 women included in the data had been followed for 18 years, with 5 assessments of diet and nutrient intake. During the followup period, 4,107 women developed invasive breast cancer. Those who ate the most animal protein had a two percent higher risk of breast cancer, while those who ate the most red meat had a 7 percent lower risk of breast cancer, and those who ate the most meat of all kinds had an 11 percent lower risk of breast cancer.

HRT Does not Improve Quality of Life in Women Without Menopausal Symptoms
Last summer the Women’s Health Initiative (WHI) rocked the world of conventional hormone replacement therapy (HRT) when one arm of the study was halted early because of clear increased health risks to women using PremPro. Now, further analysis from this study published in the New England Journal of Medicine is showing that when women who don’t have menopausal symptoms are put on PremPro, the most commonly used form of HRT, they do not experience an increase in their quality of life compared to women on a placebo. What can one say to this? Duh? If it ain’t broke, don’t fix it? However, this research was presumably done because of the habit that conventional doctors had, prior to last summer, of putting every woman over the age of fifty on a one-dose-fits-all HRT regimen. The broad consequences of that mechanistic mindset are estrogen dominance and progestin side effects, and the specific consequences, as we saw in the WHI, can range from weight gain and mood swings to fatal blood clots and breast cancer.
Editorial comments on the newly published research suggested that only women with menopausal symptoms should be put on PremPro, but that’s hardly the point. The point is that doctors should be measuring saliva hormone levels first, and then giving only what is deficient, in small, physiologic doses of natural hormones. (N Engl J Med. Published online March 17, 2003)

Progesterone Protects the Uterus
It was very rewarding to receive a phone call from Dr. Helene Leonetti telling me that her study comparing PremPro with Premarin and progesterone cream was complete, was soon to be published in a major peer-reviewed medical journal, and that it is to receive third prize at the American College of Obstetricians and Gynecologists Annual Clinical Meeting this spring.
Dr. Leonetti’s study effectively proves that progesterone cream protects the uterine lining (the endometrium) as well as progestins do. Most of you know that in conventional medicine, women who have a uterus are always supposed to be given a progestin along with their estrogen to protect them from uterine cancer. In spite of the many negative side effects of the progestins, many doctors have hesitated to prescribe progesterone cream instead, for fear it would not protect the endometrium. In Dr. Leonetti’s study, uterine tissue was examined before, during, and after using either PremPro (Premarin plus Provera) or a combination of Premarin and progesterone cream. The group using progesterone cream was found to be as well protected as the PremPro group. This should put to rest any concerns that physicians may have about using progesterone cream for hormone replacement.

Conventional Medicine Gives itself a Failing Grade
I was happy to see that the Journal of the American Medical Association (JAMA) is looking at itself and its competitors with a critical eye. According to the Associated Press, one study “reviewed 359 studies published between 1989 and 1998 in JAMA, the New England Journal of Medicine, the Lancet, the British Medical Journal and Annals of Internal Medicine. Only 26 studies reported straightforward statistics that clearly assessed the effect on patients.”

Lobular Breast Cancer Rates Skyrocketing
The incidence of lobular breast cancer more than doubled between 1987 and 1999, according to a study from the Fred Hutchinson Cancer Research Center in Seattle. The incidence of invasive ductal carcinoma, which is more common, remained stable during the same time period, and the rate of mixed ductal-lobular carcinoma nearly doubled. Lobular carcinoma is the type of breast cancer most frequently associated with the use of PremPro.
JAMA 2003;289:1421-1424.

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Books
For more detailed information on natural hormone balance, read one of Dr. Lee's books !


What Your Doctor May Not Tell You About Breast Cancer
Breast CancerJohn R. Lee, M.D., David Zava Ph.D.. and Virginia Hopkins

Order on-line for $20.00 (23% discount) plus $4.95 shipping and handling.


What Your Doctor May Not Tell You About Menopause
John R. Lee, M.D., and Virginia Hopkins

Order on-line for $14.95 plus $4.95 shipping and handling.


What Your Doctor May Not Tell You About Premenopause
John R. Lee, M.D., and Virginia Hopkins

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About Breast Cancer
Audio cassette or CD. John R. Lee, M.D. talks about breast cancer.
Order $12.95


About Hormone Replace-ment
Audio cassette or CD. John R. Lee, M.D. talks about Hormone Replacement.
Order on-line


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